Unscripted - The AMCP Podcast

In this episode of Unscripted, host Steven Kheloussi, PharmD, MBA, FAMCP, Principal Consultant at Kheloussi Consulting, LLC, is joined by Harrison Nguyen, MD, MBA, MPH, DTM&H, FAAD, Managing Director at Harrison Dermatology & Research Group, to explore the evolving psoriasis treatment landscape and the importance of recognizing psoriasis as a systemic inflammatory condition. They discuss the benefits of early intervention, achieving complete skin clearance, managing comorbidities, and tailoring treatment to individual patient needs. The conversation also examines the challenges of treatment access, formulary decisions, and emerging clinical guidelines, highlighting important considerations for managed care professionals. This episode is sponsored by AbbVie Inc.

In this episode of Unscripted, Steve Kheloussi, Principal Consultant with Kheloussi Consulting, speaks with Dr. Kirollos Hanna, Director of Pharmacy at Minnesota Oncology and Assistant Professor of Pharmacy at the Mayo Clinic College of Medicine, about precision oncology in advanced breast cancer and the role of managed care. They discuss the evolving use of biomarker testing and circulating tumor DNA to identify ESR1 mutations, considerations for coverage and prior authorization, and the need to better align laboratory, medical, and pharmacy benefits as new evidence and treatment approaches emerge.

In this episode of Unscripted, Jessica Fann, Program Director for Research and Strategic Partnerships at Vanderbilt Specialty Pharmacy, is joined by Jason Dranove, MD, Medical Director of the Gastroenterology and Motility Program at Atrium Health Levine Children’s Hospital and Associate Professor of Pediatrics at Wake Forest University School of Medicine, to discuss pediatric IBS-C and functional constipation. They explore current treatment challenges, the expanded pediatric indication for Linzess, its clinical evidence and safety profile, and what new treatment options may mean for patients, families, providers, and managed care.

In this episode of Unscripted, Steve Kheloussi, Principal Consultant with Kheloussi Consulting, speaks with Rachel Unger, Director of Research and Data Analytics at the Economic Alliance for Michigan, about bringing employers, health plans, providers, and patient advocates together to improve access to evidence-based precision oncology care. They discuss biomarker testing, payer coverage policies, the importance of aligning testing and treatment decisions, and practical steps health plans can take to reduce barriers while supporting high-quality, cost-effective cancer care.

In this episode of Unscripted, guest host Steve Kheloussi, PharmD, MBA, FAMCP, welcomes returning guest Dr. Arash Mostaghimi, MD, MPA, MPH, Associate Professor of Dermatology at Harvard Medical School and Vice Chair of Clinical Trials and Innovation and Director of the Dermatology Inpatient Service at Brigham and Women’s Hospital, to discuss the rapidly evolving treatment landscape for alopecia areata. Once a condition with no FDA-approved therapies, alopecia areata now has three approved JAK inhibitors—with a fourth potentially on the horizon—and new clinical guidelines that may reshape how disease severity is defined and treated. Dr. Mostaghimi explains why traditional measures such as SALT scores may not fully capture the burden of disease, how the new AASC framework incorporates psychosocial impact, and what these changes could mean for coverage decisions, step therapy requirements, and formulary management. Sponsored by AbbVie, Inc.

In this episode of Unscripted, host Steve Kheloussi, PharmD, principal consultant with Kheloussi Consulting and a managed care pharmacist, is joined by Tianyi Wang, consultant at Omnicom Health Market Access, and Irvin Molina, PharmD, BCOP, director of clinical pharmacy at IPD Analytics and a board-certified oncology pharmacist, to explore how National Comprehensive Cancer Network (NCCN) guidelines influence payer policy and patient access in non-small cell lung cancer (NSCLC).

In this episode of Unscripted, Dr. Ryan Haumschild, Vice President of Pharmacy at Emory, is joined by Dr. Naveen Pemmaraju, Professor of Leukemia and founding director of the BPDCN program at MD Anderson, to discuss blastic plasmacytoid dendritic cell neoplasm (BPDCN), an ultra-rare and aggressive blood cancer. They examine the recent FDA approval of pivekimab sunirine-pvzy (PVEK), a CD123-directed antibody-drug conjugate, and results from the CADENZA trial in both treatment-naive and relapsed or refractory patients. The conversation explores where PVEK may fit within the evolving BPDCN treatment landscape, its safety and outpatient administration, and the role of targeted therapies in helping eligible patients reach stem cell transplant. Sponsored by Abbvie.

In this episode of AMCP Unscripted, host Amy Lugo, PharmD, BCPS, BC-ADM, FAPhA, FAMCP, Founder and CEO of LoneStar Health Solutions, is joined by Dr. Joshua Lennon, Assistant Professor at the University of Tennessee Health Science Center, to discuss the unique challenges of diagnosing and treating narcolepsy in children. They explore why pediatric narcolepsy is frequently misdiagnosed, the significant delays many patients experience before receiving an accurate diagnosis, and the impact untreated symptoms can have on learning, social development, and long-term health. The conversation also examines current FDA-approved treatment options, promising advances in orexin-targeted therapies, and the important role managed care professionals play in improving timely access to evidence-based care for children living with narcolepsy.

Today on Unscripted, guest host Denise Wolff, PharmD, CEO & Founder of Denise & Co., LLC, welcomes Zachary Contreras, PharmD, RPh, Director of Pharmacy Benefits, Sharp Health Plan, for a discussion on idiopathic hypersomnia (IH), a chronic neurological sleep disorder that remains widely underrecognized despite its profound impact on patients’ lives. Together, they explore the challenges of diagnosing IH, including a diagnostic delay that can exceed a decade, the significant burden the condition places on work, relationships, education, and overall quality of life, and the reasons many patients remain invisible within healthcare systems. The episode highlights practical steps health plans can take today to reduce barriers to care, improve long-term outcomes, and help patients with idiopathic hypersomnia receive the diagnosis and treatment they need sooner. Sponsored by Jazz Pharmaceuticals.

Platinum-resistant ovarian cancer remains one of the most challenging settings in oncology, with limited treatment options and historically poor outcomes for many patients. In this episode of Unscripted, the AMCP Podcast, guest host Abby Kim, PharmD, BCOP, Senior Director of Clinical Strategy and Oncology Specialty Solutions at Prime Therapeutics, sits down with Kathleen Moore, MD, Deputy Director of the Fred & Pamela Buffett Cancer Center and Professor of Obstetrics and Gynecology at Nebraska Medicine, to discuss the evolving treatment landscape for recurrent ovarian cancer and the growing role of biomarker-driven care. Dr. Moore explores the history and challenges of treating platinum-resistant disease, reviews the clinical evidence behind ELAHERE® (mirvetuximab soravtansine-gynx), examines the importance of folate receptor alpha testing, and shares insights on treatment sequencing, patient-reported outcomes, safety and tolerability considerations, and emerging therapies that may further expand options for patients and inform decision-making across managed care. Sponsored by Abbvie, Inc.